Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response

Angew Chem Int Ed Engl. 2013 Jun 10;52(24):6218-21. doi: 10.1002/anie.201300178. Epub 2013 Apr 29.

Authors

Hiroyasu Takemoto¹, Kanjiro Miyata, Shota Hattori, Takehiko Ishii, Tomoya Suma, Satoshi Uchida, Nobuhiro Nishiyama, Kazunori Kataoka

Affiliation

¹ Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan.

PMID: 23630117
DOI: 10.1002/anie.201300178

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acids / metabolism*
Endosomes / metabolism*
Hydrogen-Ion Concentration*
Interferon-alpha / metabolism*
RNA, Small Interfering / metabolism*

Substances

Acids
Interferon-alpha
RNA, Small Interfering