Breakthrough disseminated cryptococcosis during micafungin therapy

J Microbiol Immunol Infect. 2015 Aug;48(4):456-8. doi: 10.1016/j.jmii.2013.03.002. Epub 2013 Apr 28.

Abstract

Echinocandins are not active against basidiomycetous yeasts, such as Cryptococcus neoformans, Trichosporon, and Rhodotorula species, and zygomycosis. We present a patient with renal failure and candidemia, who developed a breakthrough fungal infection with cryptococcemia and cryptococcuria while receiving micafungin therapy.

Keywords: Breakthrough fungal infection; Cryptococcosis; Micafungin.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antifungal Agents / therapeutic use*
  • Candidiasis / complications
  • Cryptococcosis / complications*
  • Cryptococcosis / drug therapy*
  • Cryptococcus neoformans / isolation & purification*
  • Echinocandins / therapeutic use*
  • Fungemia / diagnosis*
  • Fungemia / pathology*
  • Humans
  • Lipopeptides / therapeutic use*
  • Male
  • Micafungin
  • Renal Insufficiency / complications

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Micafungin