Abstract
Stabilization of G-quadruplex inhibits the activity of the enzyme telomerase in cancer cells. We found LL37, a host defense human cathelicidin antimicrobial peptide, to be a potent binder of G-quadruplex structures.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antimicrobial Cationic Peptides / chemistry*
-
Antimicrobial Cationic Peptides / metabolism
-
Cathelicidins
-
Circular Dichroism
-
G-Quadruplexes*
-
Humans
-
Models, Molecular
-
Molecular Structure
-
Protein Binding
-
Telomere / chemistry*
-
Telomere / metabolism
Substances
-
Antimicrobial Cationic Peptides
-
Cathelicidins