Abstract
A new 6/6/5/6-fused limonoid, phyllanthoid A (1), possessing both 19/30 and 19/29 oxygen bridges was isolated from Phyllanthus cochinchinensis (Euphorbiaceae), together with a new related limonoid, phyllanthoid B (2). Their structures were determined by spectroscopic analysis and single-crystal X-ray diffraction in the case of 1. Compound 1 displayed moderate antifeedant against the generalist plant-feeding insect Spodoptera exigua and cytotoxicity against the MCF-7 cell line.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cell Line, Tumor
-
Crystallography, X-Ray
-
Feeding Behavior / drug effects*
-
Humans
-
Larva
-
Limonins / chemistry*
-
Limonins / isolation & purification
-
Limonins / pharmacology
-
MCF-7 Cells
-
Magnetic Resonance Spectroscopy
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Phyllanthus / chemistry*
-
Plant Extracts / chemistry*
-
Plant Extracts / isolation & purification
-
Plant Extracts / pharmacology
Substances
-
Limonins
-
Plant Extracts
-
phyllanthoid A
-
phyllanthoid B