Positivity of serum "classical" onconeural antibodies in a series of 2063 consecutive patients with suspicion of paraneoplastic neurological syndrome

J Neuroimmunol. 2013 Jun 15;259(1-2):75-80. doi: 10.1016/j.jneuroim.2013.04.007. Epub 2013 Apr 30.

Abstract

This study determined the prevalence of classical onconeural Ab in a series of 2063 consecutive patients that were investigated because of suspicion of PNS as well as evaluated individual onconeural Ab in relationship to the clinical spectrum of associated neurological syndromes and tumor types detected in 70 patients finally diagnosed with PNS. We conclude that detectability of onconeural Ab is low among patients suspected with PNS. Specification of Ab is helpful in defining a neurological syndrome as paraneoplastic as well as in searching of underlying tumor. The success in tumor screening depends on the type of onconeural Ab.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Neoplasm / blood
  • Autoantibodies / blood*
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / immunology
  • Female
  • Humans
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / immunology
  • Lymphoma / epidemiology
  • Lymphoma / immunology
  • Male
  • Middle Aged
  • Neoplasms / epidemiology*
  • Neoplasms / immunology*
  • Ovarian Neoplasms / epidemiology
  • Ovarian Neoplasms / immunology
  • Paraneoplastic Syndromes, Nervous System / epidemiology*
  • Paraneoplastic Syndromes, Nervous System / immunology*
  • Seroepidemiologic Studies
  • Uterine Neoplasms / epidemiology
  • Uterine Neoplasms / immunology
  • Young Adult

Substances

  • Antibodies, Neoplasm
  • Autoantibodies