Fructose-1,6-bisphosphate reduces ATP loss from hypoxic astrocytes

Brain Res. 1990 May 21;516(2):310-2. doi: 10.1016/0006-8993(90)90932-2.

Abstract

Hypoxia caused injury and metabolic dysfunction of astrocytes, as indicated by a time-dependent loss of lactate dehydrogenase (LDH) activity and ATP content. The combination of 3.5 mM fructose-1,6-bisphosphate (FBP) and 7.5 mM glucose (GLC) reduced the decrease of ATP and prevented the loss of LDH. These data indicate that the combination of GLC + FBP protects astrocytes from hypoxia. The results also suggest that the maintainance of ATP concentration is the mechanism by which FBP prevents hypoxic injury.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Animals
  • Astrocytes / cytology
  • Astrocytes / drug effects
  • Astrocytes / metabolism*
  • Cell Hypoxia / drug effects*
  • Cells, Cultured
  • Cerebral Cortex / cytology
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism*
  • Fructosediphosphates / pharmacology*
  • Hexosediphosphates / pharmacology*
  • Rats
  • Rats, Inbred Strains

Substances

  • Fructosediphosphates
  • Hexosediphosphates
  • Adenosine Triphosphate
  • fructose-1,6-diphosphate