Ten-year retrospective study of head and neck carcinoma in situ: incidence, treatment, and clinical outcome

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Aug;116(2):174-8. doi: 10.1016/j.oooo.2013.03.002. Epub 2013 May 1.

Abstract

Objectives: To examine the management and clinical outcome for patients with primary head and neck carcinoma in situ (CIS) and to estimate the incidence in the referral population.

Study design: A retrospective study from 2000-2009 of patients with head and neck CIS referred for treatment at Rigshospitalet. The referral area was East Denmark and Greenland with a population of 2.4 million.

Results: Fifty-five patients with primary CIS were identified: 21 oral cavity, 7 pharynx, 25 larynx, 2 nasal cavity/paranasal sinuses. The median annual incidence was 0.24/100,000. Eleven patients (20%) had T-site recurrence. The 5-year disease-specific survival rate and 5-year recurrence-free survival rate were 98% and 74% respectively.

Conclusions: The annual incidence of primary head and neck CIS was low and in accordance with previous findings reported in the literature. We recommend that CIS lesions should be treated on T-site and surveilled as T1/T2 head and neck carcinomas.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma in Situ / epidemiology*
  • Denmark / epidemiology
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Greenland / epidemiology
  • Head and Neck Neoplasms / epidemiology*
  • Humans
  • Incidence
  • Laryngeal Neoplasms / epidemiology
  • Male
  • Middle Aged
  • Mouth Neoplasms / epidemiology
  • Neoplasm Grading
  • Neoplasm Recurrence, Local / epidemiology
  • Nose Neoplasms / epidemiology
  • Pharyngeal Neoplasms / epidemiology
  • Retrospective Studies
  • Treatment Outcome