A retrospective audit of 200 cases of CNS tumours and their surgical management in a tertiary care centre

Ir J Med Sci. 2013 Dec;182(4):697-701. doi: 10.1007/s11845-013-0959-1. Epub 2013 May 4.

Abstract

Aims: To study the nature of the tumours managed in the Irish population.

Methods: This audit research was completed via a retrospective medical review on 200 patients with CNS tumours managed in a tertiary care centre between 2008 and 2009.

Results: The mean age was 53 years. The male:female ratio was 2:1. The majority were glioblastomas and astrocytomas. Grade IV tumours were predominant (65.5 %). Headaches (37 %), motor weakness (32 %) and seizures (25.5 %) were the highest presentations. The commonest sites affected were the left parietal and left temporal lobes. There were 17.5 % operative morbidities with motor weakness (22.9 %), seizure (14.3 %) and thrombo-embolism (14.3 %) dominating and significant association to surgical radicality (p = 0.041). 3.5 % operative mortalities were reported. 52.5 and 62.5 % of patients received adjuvant chemotherapy and radiotherapy, respectively.

Conclusions: Patients with CNS tumours typically had multiple presentations. More extensive surgical resection was associated with higher postoperative morbidities (p = 0.041). The 30-day postoperative morbidity (17.5 %) and mortality (3.5 %) were concordant with the currently available literature.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Astrocytoma / complications
  • Astrocytoma / mortality
  • Astrocytoma / surgery*
  • Central Nervous System Neoplasms / complications
  • Central Nervous System Neoplasms / mortality
  • Central Nervous System Neoplasms / surgery*
  • Chemotherapy, Adjuvant
  • Child
  • Child, Preschool
  • Female
  • Glioblastoma / complications
  • Glioblastoma / mortality
  • Glioblastoma / surgery*
  • Headache / etiology
  • Humans
  • Infant
  • Ireland
  • Male
  • Medical Audit
  • Middle Aged
  • Motor Neuron Disease / etiology
  • Neoplasm Grading
  • Neurosurgical Procedures* / adverse effects
  • Neurosurgical Procedures* / mortality
  • Radiotherapy, Adjuvant
  • Retrospective Studies
  • Seizures / etiology
  • Tertiary Care Centers
  • Thromboembolism / etiology
  • Treatment Outcome
  • Young Adult