Antioxidant properties and UV absorbance pattern of mycosporine-like amino acids analogs synthesized in an environmentally friendly manner

J Biochem Mol Toxicol. 2013 Jun;27(6):305-12. doi: 10.1002/jbt.21489. Epub 2013 May 3.

Abstract

In current study, we report efficient and clean procedure for preparing mycosporine-like amino acids (MMAs) analogs and evaluate their ultraviolet absorbance properties and antioxidant activities. The ultraviolet radiation absorbance patterns of the compounds were recorded and then used to define their molar absorptivities. The antioxidant activities were assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and superoxide radical scavenging assays. Eight of nine compounds showed good activity against superoxide radicals, as only one of the analogs exhibited a measurable IC50 in the DPPH assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemical synthesis
  • Amino Acids / pharmacology*
  • Antioxidants / chemical synthesis
  • Antioxidants / pharmacology*
  • Biphenyl Compounds
  • Cyclohexanes / chemical synthesis
  • Cyclohexanes / pharmacology*
  • Free Radical Scavengers / chemical synthesis
  • Free Radical Scavengers / pharmacokinetics
  • Green Chemistry Technology / methods
  • Molecular Structure
  • Picrates
  • Radiation-Protective Agents / chemical synthesis
  • Radiation-Protective Agents / pharmacology*
  • Spectrophotometry, Ultraviolet
  • Ultraviolet Rays

Substances

  • Amino Acids
  • Antioxidants
  • Biphenyl Compounds
  • Cyclohexanes
  • Free Radical Scavengers
  • Picrates
  • Radiation-Protective Agents
  • 1,1-diphenyl-2-picrylhydrazyl