Abstract
Honokiol (3,5-di-(2-propenyl)-1,1-biphenyl-2,2-diol) is a natural bioactive neolignan isolated from the genus Magnolia. In recent studies, honokiol has been observed to have anti-angiogenic, anticancer, anti-inflammatory, neuroprotective and GABA-modulating properties in vitro and in preclinical models. Honokiol and its analogs target multiple signaling pathways including NF-κB, STAT3, EGFR, mTOR and caspase-mediated common pathway, which regulate cancer initiation and progression. Honokiol and its targets of action may be helpful in the development of effective analogs and targeted cancer therapy. In this review, recent data describing the molecular targets of honokiol and its analogs with anticancer and some other bioactivities are discussed.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use
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Biphenyl Compounds / chemistry*
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Biphenyl Compounds / pharmacology
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Biphenyl Compounds / therapeutic use
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Caspases / chemistry
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Caspases / metabolism
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Humans
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Lignans / chemistry*
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Lignans / pharmacology
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Lignans / therapeutic use
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Magnolia / chemistry
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NF-kappa B / antagonists & inhibitors
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NF-kappa B / metabolism
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Neoplasms / drug therapy
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Phosphatidylinositol 3-Kinases / metabolism
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Phosphoinositide-3 Kinase Inhibitors
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Phospholipase D / antagonists & inhibitors
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Phospholipase D / metabolism
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Signal Transduction / drug effects
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Structure-Activity Relationship
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TOR Serine-Threonine Kinases / antagonists & inhibitors
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TOR Serine-Threonine Kinases / metabolism
Substances
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Antineoplastic Agents, Phytogenic
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Biphenyl Compounds
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Lignans
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NF-kappa B
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Phosphoinositide-3 Kinase Inhibitors
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honokiol
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TOR Serine-Threonine Kinases
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Phospholipase D
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Caspases