Abstract
In this open, clinically based, weight modification program, we determined in six sedentary obese adults (five women; one male; age range 30-62 years) that the combination of a modified calorie diet plus PGX® meal replacement and PGX® supplementation resulted in a significant reduction in several cardiovascular risk factors over a 12-week time period. This included a significant improvement in lipids (-0.98 mmol/l LDL-C), reduction in average weight (-9.2 kg), mean reduction in fat (-4.1%) and an increase in fat-free mass (2.8%).
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipose Tissue / drug effects
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Adult
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Alginates / pharmacology
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Alginates / therapeutic use
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Body Composition / drug effects*
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Body Fluid Compartments / drug effects
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Caloric Restriction*
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Cardiovascular Diseases / etiology
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Cardiovascular Diseases / prevention & control*
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Cholesterol, LDL / blood
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Diet, Reducing
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Dietary Fiber / pharmacology
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Dietary Fiber / therapeutic use*
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Dietary Supplements
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Female
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Glucuronic Acid / pharmacology
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Glucuronic Acid / therapeutic use
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Hexuronic Acids / pharmacology
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Hexuronic Acids / therapeutic use
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Humans
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Male
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Mannans / pharmacology
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Mannans / therapeutic use
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Middle Aged
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Obesity / blood
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Obesity / diet therapy*
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Polysaccharides, Bacterial / pharmacology
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Polysaccharides, Bacterial / therapeutic use
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Risk Factors
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Sedentary Behavior
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Weight Loss / drug effects*
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Weight Reduction Programs*
Substances
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Alginates
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Cholesterol, LDL
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Dietary Fiber
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Hexuronic Acids
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Mannans
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Polysaccharides, Bacterial
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(1-6)-alpha-glucomannan
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Glucuronic Acid
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xanthan gum