Discovering what makes STAT signaling TYK in T-ALL

Cancer Discov. 2013 May;3(5):494-6. doi: 10.1158/2159-8290.CD-13-0123.

Abstract

RNA interference screening establishes TYK2 dependence in T-cell acute lymphoblastic leukemia (T-ALL), leading to identification of TYK2-activating mutations and increased IL-10 receptor signaling in T-ALL cell lines. Cancer Discov; 3(5); 494-6. ©2013 AACR.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Proto-Oncogene Proteins c-bcl-2 / metabolism*
  • STAT1 Transcription Factor / metabolism*
  • TYK2 Kinase / metabolism*

Substances

  • Proto-Oncogene Proteins c-bcl-2
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • TYK2 Kinase