NS3 of bluetongue virus interferes with the induction of type I interferon

J Virol. 2013 Jul;87(14):8241-6. doi: 10.1128/JVI.00678-13. Epub 2013 May 8.

Abstract

Upon infection with Bluetongue virus (BTV), an arthropod-borne virus, type I interferon (IFN-I) is produced in vivo and in vitro. IFN-I is essential for the establishment of an antiviral cellular response, and most if not all viruses have elaborated strategies to counteract its action. In this study, we assessed the ability of BTV to interfere with IFN-I synthesis and identified the nonstructural viral protein NS3 as an antagonist of the IFN-I system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Western
  • Bluetongue virus / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • HEK293 Cells
  • Humans
  • Immunity, Innate / drug effects
  • Immunity, Innate / immunology*
  • Interferon Type I / antagonists & inhibitors*
  • Interferon Type I / biosynthesis
  • Luciferases
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction / drug effects
  • Signal Transduction / immunology*
  • Viral Nonstructural Proteins / metabolism*
  • Viral Nonstructural Proteins / pharmacology

Substances

  • Interferon Type I
  • S10 protein, Bluetongue virus
  • Viral Nonstructural Proteins
  • Luciferases