Abstract
Therapy of rats with CCl4 hepatitis with Stellaria media L. water-soluble polysaccharide fraction in a dose of 100 mg/kg reduces serum activities of transaminases (ALT and AST), alkaline phosphatase, bilirubin, and the thymol test values. In the liver, the density of inflammatory infiltration of the organ parenchyma, total count of necrotic hepatocytes, fatty and protein degeneration are reducing. Hence, water-soluble polysaccharide fraction, isolated from the terrestrial part of Stellaria media L., is characterized by hepatoprotective activity.
MeSH terms
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Alanine Transaminase / blood
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Alanine Transaminase / metabolism
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Alkaline Phosphatase / blood
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Alkaline Phosphatase / metabolism
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Animals
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Aspartate Aminotransferases / blood
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Aspartate Aminotransferases / metabolism
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Bilirubin / blood
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Bilirubin / metabolism
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Carbon Tetrachloride
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Hepatitis / drug therapy*
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Hepatocytes / drug effects
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Liver / drug effects*
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Liver / pathology
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Liver Function Tests
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Male
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Phytotherapy
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Plant Preparations / therapeutic use*
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Polysaccharides / therapeutic use
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Rats
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Solubility
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Stellaria / chemistry*
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Thymolphthalein / analogs & derivatives
Substances
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Plant Preparations
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Polysaccharides
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thymol blue
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Carbon Tetrachloride
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Aspartate Aminotransferases
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Alanine Transaminase
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Alkaline Phosphatase
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Bilirubin
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Thymolphthalein