Elevated circulating cytotoxic T lymphocyte-associated antigen-4 levels are related to lung function and inflammation in chronic obstructive pulmonary disease

Yongchun Shen; Ting Yang; Tao Wang; Lei Chen; Fuqiang Wen

doi:10.1111/resp.12113

Elevated circulating cytotoxic T lymphocyte-associated antigen-4 levels are related to lung function and inflammation in chronic obstructive pulmonary disease

Respirology. 2013 Jul;18(5):885-6. doi: 10.1111/resp.12113.

Authors

Yongchun Shen¹, Ting Yang, Tao Wang, Lei Chen, Fuqiang Wen

Affiliation

¹ Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China.

PMID: 23659585
DOI: 10.1111/resp.12113

Abstract

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is involved in immune and inflammation regulation. The present study aimed to investigate the association between CTLA-4 and COPD. Data revealed that serum levels of CTLA-4 were elevated in COPD patients, inversely correlated with lung function and positively correlated with serum C-reactive protein levels in the COPD group. These findings suggest that CTLA-4 may play a role in COPD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Biomarkers / blood
C-Reactive Protein / metabolism
CTLA-4 Antigen / blood*
Female
Humans
Lung / physiopathology*
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive / blood
Pulmonary Disease, Chronic Obstructive / physiopathology*
Regression Analysis

Substances

Biomarkers
CTLA-4 Antigen
C-Reactive Protein