Abstract
An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1' specificity loop, representing the first step in the selective inhibition process (PDB ID code 4JA1).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry
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Coordination Complexes / metabolism
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Crystallography, X-Ray
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Matrix Metalloproteinase 3 / chemistry
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Matrix Metalloproteinase 3 / metabolism*
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Matrix Metalloproteinase Inhibitors / chemistry*
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Matrix Metalloproteinase Inhibitors / metabolism
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Platinum / chemistry*
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Protein Binding
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Protein Structure, Tertiary
Substances
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Coordination Complexes
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Matrix Metalloproteinase Inhibitors
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Platinum
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Matrix Metalloproteinase 3
Associated data
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PDB/4DPE
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PDB/4G9L
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PDB/4JA1