Mechanically tunable, self-adjuvanting nanoengineered polypeptide particles

Jiwei Cui; Robert De Rose; James P Best; Angus P R Johnston; Sheilajen Alcantara; Kang Liang; Georgina K Such; Stephen J Kent; Frank Caruso

doi:10.1002/adma.201300981

Mechanically tunable, self-adjuvanting nanoengineered polypeptide particles

Adv Mater. 2013 Jul 5;25(25):3468-72. doi: 10.1002/adma.201300981. Epub 2013 May 10.

Authors

Jiwei Cui¹, Robert De Rose, James P Best, Angus P R Johnston, Sheilajen Alcantara, Kang Liang, Georgina K Such, Stephen J Kent, Frank Caruso

Affiliation

¹ Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.

PMID: 23661596
DOI: 10.1002/adma.201300981

Abstract

DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.

Keywords: CpG; adjuvants; mesoporous silica; nanotechnology; polypeptide particles; vaccine delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic / chemistry
Adjuvants, Immunologic / metabolism*
Adjuvants, Immunologic / pharmacology*
Base Sequence
CpG Islands
Dendritic Cells / drug effects
Dendritic Cells / immunology
Drug Carriers / metabolism
Humans
Mechanical Phenomena*
Nanotechnology*
Oligonucleotides / chemistry
Oligonucleotides / genetics
Oligonucleotides / metabolism
Peptides / metabolism*
Polyglutamic Acid / chemistry
Protein Engineering*

Substances

Adjuvants, Immunologic
Drug Carriers
Oligonucleotides
Peptides
Polyglutamic Acid