Abstract
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system with autoimmune characteristics. Serum immunoglobulin G autoantibodies have been identified in the majority of NMO patients with the water channel aquaporin-4 (AQP4) as their main target autoantigen. Clinical criteria have defined NMO and NMO-spectrum disease. The clinical features include inflammation of the optic nerve.
MeSH terms
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Aquaporin 4 / cerebrospinal fluid
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Aquaporin 4 / immunology
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Autoantibodies / cerebrospinal fluid
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Autoantibodies / immunology
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Humans
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Immunoglobulin G / cerebrospinal fluid
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Magnetic Resonance Imaging
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Myelitis, Transverse / etiology
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Neuromyelitis Optica / classification
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Neuromyelitis Optica / diagnosis*
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Neuromyelitis Optica / epidemiology
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Neuromyelitis Optica / immunology
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Optic Neuritis / etiology
Substances
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Aquaporin 4
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Autoantibodies
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Immunoglobulin G