Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger

Angew Chem Int Ed Engl. 2013 Jun 24;52(26):6633-7. doi: 10.1002/anie.201302098. Epub 2013 May 13.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / drug effects
  • Calcium / metabolism*
  • Calcium Signaling
  • Cyclic ADP-Ribose / analogs & derivatives*
  • Cyclic ADP-Ribose / chemical synthesis
  • Cyclic ADP-Ribose / chemistry*
  • Drug Design
  • Humans
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Jurkat Cells
  • Microsomes / drug effects
  • Molecular Conformation
  • Nucleotides / chemistry
  • Rats
  • Second Messenger Systems*
  • Stereoisomerism
  • Sulfhydryl Compounds / chemistry

Substances

  • Nucleotides
  • Sulfhydryl Compounds
  • Cyclic ADP-Ribose
  • Calcium