Abstract
Alopecia can be caused by defective formation, defective regeneration, or increased destruction of hair follicles. Much work has elucidated the roles of diffusible morphogens in modulating hair follicle stem cell activities. Recent studies have revealed novel molecular events within the nucleus, which are required for the activation and progression of hair stem cells. These studies will provide new clues and targets for designing therapeutic strategies for hair loss.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics*
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Alopecia / genetics*
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Animals
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Cell Cycle Proteins
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Epidermal Cells*
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Epidermis / growth & development*
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Female
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Male
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Phosphoproteins / genetics*
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Stem Cells / physiology*
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YAP-Signaling Proteins
Substances
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Adaptor Proteins, Signal Transducing
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Cell Cycle Proteins
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Phosphoproteins
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YAP-Signaling Proteins
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Yap1 protein, mouse