A rare der(Y)t(Y;1)(q12;q12) in a patient with post-polycythemic myelofibrosis: a case report

Masahiro Manabe; Osami Takeda; Junya Okita; Teruhito Takakuwa; Naonori Harada; Hirofumi Nakano; Shuichiro Okamoto; Yasutaka Aoyama; Takeo Kumura; Tadanobu Ohta; Yoshio Furukawa; Atsuko Mugitani

A rare der(Y)t(Y;1)(q12;q12) in a patient with post-polycythemic myelofibrosis: a case report

Am J Blood Res. 2013 May 5;3(2):186-90. Print 2013.

Authors

Masahiro Manabe¹, Osami Takeda, Junya Okita, Teruhito Takakuwa, Naonori Harada, Hirofumi Nakano, Shuichiro Okamoto, Yasutaka Aoyama, Takeo Kumura, Tadanobu Ohta, Yoshio Furukawa, Atsuko Mugitani

Affiliation

¹ Department of Hematology, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.

PMID: 23675569
PMCID: PMC3649809

Abstract

We describe a case of post-polycythemic myelofibrosis harboring der(Y)t(Y;1)(q12;q12). The patient was a 69-year-old man and was initially diagnosed with polycythemia vera. During the clinical course of his condition, the polycythemia developed into myelofibrosis. Chromosome analysis detected der(Y)t(Y;1)(q12;q12). We discuss the association between der(Y)t(Y;1)(q11~12;q12~21) and tumorigenesis along with a review of literature.

Keywords: Post-polycythemic myelofibrosis; chromosomal abnormality; der(Y)t(Y;1)(q12;q12).

Publication types

Case Reports