Luring BRCA1 to the scene of the crime

Cancer Cell. 2013 May 13;23(5):565-7. doi: 10.1016/j.ccr.2013.04.013.

Abstract

To preserve genome stability, BRCA1 must be recruited to sites of DNA damage, where BRCA1 facilitates repair of double-strand DNA breaks (DSBs). In this issue of Cancer Cell, Li and Yu report that BRCA1 recruitment involves a novel interaction between its partner protein BARD1 and poly(ADP-ribose) chains at the DSB.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • DNA Damage*
  • DNA Repair*
  • Humans
  • Ubiquitin-Protein Ligases / physiology*

Substances

  • BRAP protein, human
  • Ubiquitin-Protein Ligases