Fluorogenic probing of specific recognitions between sugar ligands and glycoprotein receptors on cancer cells by an economic graphene nanocomposite

Hai-Lin Zhang; Xiao-Li Wei; Yi Zang; Jia-Yi Cao; Shanshan Liu; Xiao-Peng He; Qibin Chen; Yi-Tao Long; Jia Li; Guo-Rong Chen; Kaixian Chen

doi:10.1002/adma.201300187

Fluorogenic probing of specific recognitions between sugar ligands and glycoprotein receptors on cancer cells by an economic graphene nanocomposite

Adv Mater. 2013 Aug 14;25(30):4097-101. doi: 10.1002/adma.201300187. Epub 2013 May 17.

Authors

Hai-Lin Zhang¹, Xiao-Li Wei, Yi Zang, Jia-Yi Cao, Shanshan Liu, Xiao-Peng He, Qibin Chen, Yi-Tao Long, Jia Li, Guo-Rong Chen, Kaixian Chen

Affiliation

¹ Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd., Shanghai, P.R. China.

PMID: 23681941
DOI: 10.1002/adma.201300187

Abstract

Economical nanocomposites based on π-stacking of N-acetyl glycosyl rhodamine B to graphene oxide (GO) are simply prepared. These "sweet" GO-materials are proven to be admirable for the fluorogenic recognition of specific intercellular sugar-based ligand-glycoprotein receptor interactions of interest.

Keywords: click chemistry; glycoprotein receptor; graphene; rhodamine; sugar.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrate Metabolism*
Glycoproteins / metabolism*
Graphite / chemistry*
Hep G2 Cells
Humans
Microscopy, Fluorescence / methods*
Molecular Probe Techniques
Nanoparticles / chemistry*
Receptors, Cell Surface / metabolism*
Rhodamines / chemistry*

Substances

Glycoproteins
Receptors, Cell Surface
Rhodamines
Graphite
rhodamine B