Stable acid-responsive electrospun biodegradable fibers as drug carriers and cell scaffolds

Macromol Biosci. 2013 Jul;13(7):885-92. doi: 10.1002/mabi.201200452. Epub 2013 May 16.

Abstract

Acid-responsive electrospun fibers are fabricated by introducing sodium bicarbonate into PLLA fibers using an emulsion method. This novel electrospun fibrous scaffold exhibits a rapid acid-responsive controlled drug release (early stage) and stable three-dimensional (3D) structure as a tissue engineering scaffold (late stage) for cell growth.

Keywords: acid-responsive; drug delivery systems; electrospun; fibrous scaffolds; tissue engineering.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials
  • Cell Proliferation / drug effects
  • Drug Carriers / chemistry*
  • Drug Carriers / therapeutic use
  • Humans
  • Lactic Acid / pharmacology
  • Polymers / chemistry
  • Polymers / therapeutic use*
  • Sodium Bicarbonate / chemistry
  • Tissue Engineering*
  • Tissue Scaffolds / chemistry*

Substances

  • Biocompatible Materials
  • Drug Carriers
  • Polymers
  • Lactic Acid
  • Sodium Bicarbonate