Cord blood endothelial colony-forming cells from newborns with congenital diaphragmatic hernia

J Pediatr. 2013 Sep;163(3):905-7. doi: 10.1016/j.jpeds.2013.04.010. Epub 2013 May 16.

Abstract

Endothelial colony-forming cells (ECFCs) are decreased in the cord blood of preterm infants with moderate-to-severe bronchopulmonary dysplasia. We quantified ECFCs from infants with congenital diaphragmatic hernia, a neonatal disorder with severe lung hypoplasia. Unlike newborns who develop bronchopulmonary dysplasia, those with congenital diaphragmatic hernia had increased and highly-proliferative cord blood ECFCs.

Keywords: BPD; Bronchopulmonary dysplasia; CDH; Congenital diaphragmatic hernia; ECFC; EPC; Endothelial colony-forming cell; Endothelial progenitor cell; MNC; Mononuclear cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Proliferation
  • Cells, Cultured
  • Endothelial Cells* / physiology
  • Female
  • Fetal Blood / cytology*
  • Hernia, Diaphragmatic / blood
  • Hernias, Diaphragmatic, Congenital*
  • Humans
  • Infant, Newborn
  • Leukocyte Count
  • Leukocytes, Mononuclear / physiology
  • Male
  • Stem Cells* / physiology