Abstract
Partially reduced oxygen species (PROS), produced by reduced heme bound Aβ peptides, can cause oxidative stress and synaptic damage in the brain, which is one of the key pathological features of Alzheimer's disease. In situ oxidation of the heme center by a physiological redox agent like Cytochrome c (Cyt c) can significantly suppress neurotoxic PROS formation. Thus, Cyt c can potentially act as a neuroprotective agent against AD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / metabolism
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Alzheimer Disease / pathology
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Amyloid beta-Peptides / chemistry*
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Amyloid beta-Peptides / metabolism
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Animals
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Brain / metabolism
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Cytochromes c / chemistry*
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Cytochromes c / metabolism
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Electron Transport
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Electrons
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Heme / chemistry*
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Humans
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Kinetics
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Oxidation-Reduction
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Oxidative Stress
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Reactive Oxygen Species / chemistry
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Reactive Oxygen Species / metabolism
Substances
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Amyloid beta-Peptides
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Reactive Oxygen Species
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Heme
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Cytochromes c