Autoimmunity in inflammatory bowel disease: a case of ulcerative colitis with diabetes mellitus, autoimmune hepatitis and autoimmune hypothyroidism

Mehri Najafi; Mohammad Mahdi Zamani; Nima Rezaei; Mozhgan Sabbaghian

Autoimmunity in inflammatory bowel disease: a case of ulcerative colitis with diabetes mellitus, autoimmune hepatitis and autoimmune hypothyroidism

Turk J Pediatr. 2012 Nov-Dec;54(6):651-3.

Authors

Mehri Najafi¹, Mohammad Mahdi Zamani, Nima Rezaei, Mozhgan Sabbaghian

Affiliation

¹ Pediatrics Center of Excellence, Children's Medical Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. [email protected].

PMID: 23692793

Abstract

Ulcerative colitis (UC) is a form of inflammatory bowel disease, which occasionally can be associated with autoimmune disorders. Herein, a two-year-old male infant with UC under sulfasalazine therapy is presented, who consequently developed type I diabetes mellitus, autoimmune hepatitis and autoimmune hypothyroidism. Although presence of concurrent autoimmune diseases with UC is a rare condition, it could highlight the role of immune-related mechanisms as a pathogenesis of disease.

Publication types

Case Reports

MeSH terms

Autoimmunity / immunology*
Colitis, Ulcerative / complications
Colitis, Ulcerative / immunology
Diabetes Mellitus, Type 1 / complications*
Diabetes Mellitus, Type 1 / immunology
Follow-Up Studies
Hashimoto Disease / complications*
Hashimoto Disease / immunology
Hepatitis, Autoimmune / complications*
Hepatitis, Autoimmune / immunology
Humans
Infant
Inflammatory Bowel Diseases / complications
Inflammatory Bowel Diseases / immunology
Male
Thyroiditis, Autoimmune

Supplementary concepts

Hypothyroidism, Autoimmune