Abstract
The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Differentiation
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Cell Proliferation
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Cell Transformation, Neoplastic / genetics
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Drosophila Proteins / genetics*
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Drosophila Proteins / metabolism
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Drosophila melanogaster / genetics*
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Drosophila melanogaster / growth & development
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Drosophila melanogaster / metabolism
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Epithelial Cells / cytology
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Epithelial Cells / metabolism
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Gene Expression Regulation, Developmental*
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / metabolism
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Mammals
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MicroRNAs / genetics
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MicroRNAs / metabolism
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Neural Stem Cells / cytology
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Neural Stem Cells / metabolism
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S Phase
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Signal Transduction
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Stem Cells / cytology
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Stem Cells / metabolism*
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Transcription Factors / genetics*
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Transcription Factors / metabolism
Substances
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DNA-Binding Proteins
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Drosophila Proteins
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MicroRNAs
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Myc protein, Drosophila
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Transcription Factors