Abstract
Immune evasion by rabies virus depends on targeting of the signal transducers and activator of transcription 1 (STAT1) and STAT2 proteins by the viral interferon antagonist P protein, but targeting of other STAT proteins has not been investigated. Here, we find that P protein associates with activated STAT3 and inhibits STAT3 nuclear accumulation and Gp130-dependent signaling. This is the first report of STAT3 targeting by the interferon antagonist of a virus other than a paramyxovirus, indicating that STAT3 antagonism is important to a range of human-pathogenic viruses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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COS Cells
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Chlorocebus aethiops
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Cytokine Receptor gp130 / metabolism*
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Green Fluorescent Proteins / metabolism
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Immune Evasion / genetics*
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Interferons / antagonists & inhibitors*
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Luciferases
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Luminescent Proteins / metabolism
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Microscopy, Confocal
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Molecular Chaperones
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Phosphoproteins / genetics
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Phosphoproteins / metabolism
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Phosphoproteins / pharmacology*
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Rabies virus / genetics*
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Rabies virus / metabolism
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Red Fluorescent Protein
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STAT3 Transcription Factor / metabolism*
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Signal Transduction / drug effects*
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Viral Structural Proteins / genetics
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Viral Structural Proteins / metabolism
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Viral Structural Proteins / pharmacology*
Substances
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Luminescent Proteins
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Molecular Chaperones
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P phosphoprotein, Rabies virus
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Phosphoproteins
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STAT3 Transcription Factor
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Viral Structural Proteins
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Cytokine Receptor gp130
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Green Fluorescent Proteins
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Interferons
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Luciferases