Abstract
Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Autophagy / immunology
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Carrier Proteins / immunology
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Carrier Proteins / metabolism
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Humans
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Inflammasomes / immunology*
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Inflammasomes / metabolism
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Inflammation Mediators / immunology*
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Inflammation Mediators / metabolism
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Interleukin-18 / immunology*
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Interleukin-18 / metabolism
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Interleukin-1beta / immunology*
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Interleukin-1beta / metabolism
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Models, Immunological
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NLR Family, Pyrin Domain-Containing 3 Protein
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Receptors, Interleukin-1 / immunology
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Receptors, Interleukin-1 / metabolism
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Signal Transduction / immunology*
Substances
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Carrier Proteins
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Inflammasomes
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Inflammation Mediators
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Interleukin-18
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Interleukin-1beta
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NLR Family, Pyrin Domain-Containing 3 Protein
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NLRP3 protein, human
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Receptors, Interleukin-1