Abstract
Hsp90, a key target in cancer therapy, has been identified as the main partner of oleocanthal, an olive oil bioactive compound. A combination of chemical and biological assays disclosed its mechanism of action at the molecular level.
MeSH terms
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Aldehydes / chemistry*
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Aldehydes / metabolism
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Binding Sites
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Cell Line, Tumor
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Cyclopentane Monoterpenes
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HSP90 Heat-Shock Proteins / antagonists & inhibitors*
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HSP90 Heat-Shock Proteins / metabolism
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HeLa Cells
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Humans
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Molecular Docking Simulation
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Olive Oil
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Phenols / chemistry*
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Phenols / metabolism
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Plant Oils / chemistry
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Protein Binding
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Proteomics*
Substances
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Aldehydes
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Cyclopentane Monoterpenes
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HSP90 Heat-Shock Proteins
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Olive Oil
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Phenols
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Plant Oils
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oleocanthal