Abstract
Peptic ulcer is one of the most common gastrointestinal disorders with complex etiology. Recently we conducted the genome wide association study for duodenal ulcer and identified disease susceptibility variations at two genetic loci corresponding to the Prostate stem cell antigen (PSCA) gene and the ABO blood group (ABO) gene. Here we investigated the association of these variations with gastric ulcer in two Japanese case-control sample sets, a total of 4,291 gastric ulcer cases and 22,665 controls. As a result, a C-allele of rs2294008 at PSCA increased the risk of gastric ulcer with odds ratio (OR) of 1.13 (P value of 5.85×10(-7)) in an additive model. On the other hand, SNP rs505922 on ABO exhibited inconsistent result between two cohorts. Our finding implies presence of the common genetic variant in the pathogenesis of gastric and duodenal ulcers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ABO Blood-Group System / genetics
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Adult
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Aged
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Antigens, Neoplasm / genetics*
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Female
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GPI-Linked Proteins / genetics
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Genetic Association Studies
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Genetic Predisposition to Disease*
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Humans
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Male
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Middle Aged
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Neoplasm Proteins / genetics*
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Polymorphism, Single Nucleotide / genetics*
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Stomach Ulcer / genetics*
Substances
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ABO Blood-Group System
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Antigens, Neoplasm
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GPI-Linked Proteins
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Neoplasm Proteins
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PSCA protein, human
Grants and funding
The Aichi part of the study was supported by a grant-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan [Priority Areas of Cancer (No. 17015018) and Innovative Areas (No. 221S0001)] and from Ministry of Health, Welfare and Labours of Japan [H24-3-G002 and H23-Application(cancer)-G002]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.