Abstract
Background:
In this study, we sequenced and phylogenetic analyses of the VP2 genes from twelve canine parvovirus (CPV) strains obtained from eleven domestic dogs and a giant panda (Ailuropoda melanoleuca) in China. A novel canine parvovirus (CPV) was detected from the giant panda in China.
Results:
Nucleotide and phylogenetic analysis of the capsid protein VP2 gene classified the CPV as a new CPV-2a type. Substitution of Gln for Arg at the conserved 370 residue in CPV presents an unusual variation in the new CPV-2a amino acid sequence of the giant panda and is further evidence for the continuing evolution of the virus.
Conclusions:
These findings extend the knowledge on CPV molecular epidemiology of particular relevance to wild carnivores.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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China
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Cluster Analysis
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DNA, Viral / chemistry
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DNA, Viral / genetics
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Dogs
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Evolution, Molecular
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Molecular Sequence Data
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Mutant Proteins / genetics
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Mutation, Missense*
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Parvovirus, Canine / classification
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Parvovirus, Canine / genetics
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Parvovirus, Canine / isolation & purification*
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Phylogeny
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Point Mutation
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Ursidae / virology*
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Viral Structural Proteins / genetics*
Substances
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DNA, Viral
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Mutant Proteins
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Viral Structural Proteins
Associated data
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GENBANK/JX624761
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GENBANK/JX624762
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GENBANK/JX624763
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GENBANK/JX624764
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GENBANK/JX624765
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GENBANK/JX624766
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GENBANK/JX624767
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GENBANK/JX624768
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GENBANK/JX624769
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GENBANK/JX624770
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GENBANK/JX624771
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GENBANK/JX624772