Heparin-induced thrombocytopenia with abdominal aortic stent-graft acute thrombosis

Ann Vasc Surg. 2013 Aug;27(6):801.e5-7. doi: 10.1016/j.avsg.2012.07.027. Epub 2013 May 24.

Abstract

We report a case of heparin-induced thrombocytopenia in a patient on low molecular weight heparin bridge therapy who developed acute abdominal aortic stent-graft thrombosis 1 week after uncomplicated endovascular abdominal aortic aneurysm repair. The diagnosis was confirmed by a computed tomographic scan of the abdomen. The patient was successfully treated by conversion to open repair. The postoperative course was marked by subacute left limb ischemia related to an in vivo cross-reactivity of danaparoid with the heparin immune complex. To our knowledge, this is the first case report of heparin-induced thrombocytopenia with acute abdominal aortic stent-graft thrombosis.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Aged
  • Anticoagulants / adverse effects
  • Anticoagulants / therapeutic use
  • Aortic Aneurysm, Abdominal / diagnostic imaging
  • Aortic Aneurysm, Abdominal / surgery*
  • Device Removal / methods*
  • Follow-Up Studies
  • Graft Occlusion, Vascular / diagnosis
  • Graft Occlusion, Vascular / etiology*
  • Graft Occlusion, Vascular / surgery
  • Heparin / adverse effects*
  • Heparin / therapeutic use
  • Humans
  • Male
  • Thrombectomy / methods*
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / complications
  • Thrombosis / diagnosis
  • Thrombosis / etiology*
  • Thrombosis / surgery
  • Tomography, X-Ray Computed
  • Ultrasonography, Doppler, Duplex

Substances

  • Anticoagulants
  • Heparin