Abstract
Two new sesquiterpene pyridine alkaloids rugosusines A and B (1 and 2), and thirty-one known compounds were isolated from the stems of Celastrus rugosus. The structures of new compounds were elucidated by detailed spectroscopic analysis, including HR-ESI-MS and 2D NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The cytotoxicities of these compounds were tested against SKOV3 and MGC-803 cell lines by CCK-8 method.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkaloids / analysis*
-
Alkaloids / chemistry
-
Alkaloids / isolation & purification
-
Alkaloids / pharmacology
-
Celastrus / chemistry*
-
Cell Line, Tumor
-
Drug Screening Assays, Antitumor
-
Drugs, Chinese Herbal / analysis
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / pharmacology
-
Humans
-
Molecular Structure
-
Plant Stems / chemistry*
-
Pyridines / analysis
-
Pyridines / chemistry
-
Pyridines / isolation & purification
-
Pyridines / pharmacology
-
Sesquiterpenes / analysis*
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / isolation & purification
-
Sesquiterpenes / pharmacology
Substances
-
Alkaloids
-
Drugs, Chinese Herbal
-
Pyridines
-
Sesquiterpenes