Abstract
A series of 4-arylimidazolones have been accessed via late-stage, palladium-mediated arylation of acetone- and cyclohexanone-derived 4-chloroimidazolones. The 4-chloroimidazolones were prepared via a novel rearrangement of the corresponding imidazolone N-oxides. This communication serves as an expansion of chemistry originally developed for our glucagon receptor antagonist program.
MeSH terms
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Catalysis
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Cyclic N-Oxides / chemical synthesis*
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Cyclic N-Oxides / chemistry*
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Cyclohexanones / chemistry
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry*
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Molecular Structure
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Palladium / chemistry
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Receptors, Glucagon / antagonists & inhibitors*
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Receptors, Glucagon / chemistry*
Substances
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Cyclic N-Oxides
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Cyclohexanones
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Imidazoles
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Receptors, Glucagon
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imidazolone
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cyclohexanone
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Palladium