Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma

J Clin Oncol. 2013 Jul 1;31(19):e324-6. doi: 10.1200/JCO.2012.46.1061. Epub 2013 May 28.
No abstract available

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Arginine
  • Back
  • Cell Survival / drug effects
  • Enzyme Activation
  • Extracellular Signal-Regulated MAP Kinases / drug effects
  • Female
  • Humans
  • Imidazoles / administration & dosage
  • Imidazoles / pharmacology
  • Indoles / administration & dosage
  • Indoles / pharmacology
  • Leucine
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / secondary
  • MAP Kinase Signaling System / drug effects*
  • Melanoma / drug therapy*
  • Melanoma / genetics
  • Niacinamide / administration & dosage
  • Niacinamide / analogs & derivatives
  • Niacinamide / pharmacology
  • Oximes / administration & dosage
  • Oximes / pharmacology
  • Phenylurea Compounds / administration & dosage
  • Phenylurea Compounds / pharmacology
  • Point Mutation*
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
  • Proto-Oncogene Proteins B-raf / genetics*
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / genetics
  • Sorafenib
  • Sulfonamides / administration & dosage
  • Sulfonamides / pharmacology
  • Vemurafenib

Substances

  • Antineoplastic Agents
  • Imidazoles
  • Indoles
  • Oximes
  • Phenylurea Compounds
  • Sulfonamides
  • Vemurafenib
  • Niacinamide
  • Arginine
  • Sorafenib
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf
  • Extracellular Signal-Regulated MAP Kinases
  • Leucine
  • dabrafenib