Concomitant vascular reconstruction during pancreatectomy for malignant disease: a propensity score-adjusted, population-based trend analysis involving 10,206 patients

JAMA Surg. 2013 Apr;148(4):331-8. doi: 10.1001/jamasurg.2013.1058.

Abstract

Objective: To assess trends in the frequency of concomitant vascular reconstructions (VRs) from 2000 through 2009 among patients who underwent pancreatectomy, as well as to compare the short-term outcomes between patients who underwent pancreatic resection with and without VR.

Design: Single-center series have been conducted to evaluate the short-term and long-term outcomes of VR during pancreatic resection. However, its effectiveness from a population-based perspective is still unknown. Unadjusted, multivariable, and propensity score-adjusted generalized linear models were performed.

Setting: Nationwide Inpatient Sample from 2000 through 2009.

Patients: A total of 10,206 patients were involved.

Main outcome measures: Incidence of VR during pancreatic resection, perioperative in-hospital complications, and length of hospital stay.

Results: Overall, 10,206 patients were included in this analysis. Of these, 412 patients (4.0%) underwent VR, with the rate increasing from 0.7% in 2000 to 6.0% in 2009 (P < .001). Patients who underwent pancreatic resection with VR were at a higher risk for intraoperative (propensity score-adjusted odds ratio, 1.94; P = .001) and postoperative (propensity score-adjusted odds ratio, 1.36; P = .008) complications, while the mortality and median length of hospital stay were similar to those of patients without VR. Among the 25% of hospitals with the highest surgical volume, patients who underwent pancreatic surgery with VR had significantly higher rates of postoperative complications and mortality than patients without VR.

Conclusions: The frequency of VR during pancreatic surgery is increasing in the United States. In contrast with most single-center analyses, this population-based study demonstrated that patients who underwent VR during pancreatic surgery had higher rates of adverse postoperative outcomes than their counterparts who underwent pancreatic resection only. Prospective studies incorporating long-term outcomes are warranted to further define which patients benefit from VR.

MeSH terms

  • Adenocarcinoma / mortality
  • Adenocarcinoma / surgery*
  • Aged
  • Chi-Square Distribution
  • Comorbidity
  • Diagnosis-Related Groups
  • Female
  • Hospital Mortality
  • Humans
  • Length of Stay / statistics & numerical data
  • Logistic Models
  • Male
  • Middle Aged
  • Pancreas / blood supply*
  • Pancreas / surgery*
  • Pancreatectomy* / mortality
  • Pancreatic Neoplasms / mortality
  • Pancreatic Neoplasms / surgery*
  • Plastic Surgery Procedures / methods*
  • Plastic Surgery Procedures / mortality
  • Postoperative Complications / epidemiology
  • Propensity Score
  • Treatment Outcome
  • United States / epidemiology
  • Vascular Surgical Procedures / methods*
  • Vascular Surgical Procedures / mortality