Concordant acute myeloblastic leukemia in monozygotic twins with germline and shared somatic mutations in the gene for CCAAT-enhancer-binding protein α with 13 years difference at onset

Haematologica. 2013 Jul;98(7):e73-4. doi: 10.3324/haematol.2012.082578. Epub 2013 May 28.
No abstract available

Keywords: acute myeloblastic leukemia; bone marrow transplantation; germline CEBPA mutations; monozygotic twins.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age Factors
  • CCAAT-Enhancer-Binding Proteins / genetics*
  • Female
  • Frameshift Mutation / genetics
  • Germ-Line Mutation / genetics*
  • Humans
  • Infant
  • Leukemia, Myeloid, Acute / diagnosis
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / pathology
  • Mutagenesis, Insertional
  • Sequence Deletion / genetics
  • Twins, Monozygotic / genetics*
  • Young Adult

Substances

  • CCAAT-Enhancer-Binding Proteins
  • CEBPA protein, human