Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant

Chem Commun (Camb). 2013 Jul 11;49(54):6030-2. doi: 10.1039/c3cc42231c.

Abstract

Copper/TEMPO catalysts can be used to prepare nitriles from aldehydes or alcohols using aqueous ammonia. Readily accessible methods were developed that enable standard glassware to be used with air as the source of O2. It was further shown that, at higher temperatures in a pressurised reactor under limiting oxygen conditions (8% O2), catalyst loadings of 1 mol% could be employed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Air
  • Alcohols / chemistry*
  • Aldehydes / chemistry*
  • Ammonia / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Cyclic N-Oxides / chemistry*
  • Nitriles / chemical synthesis*
  • Nitriles / chemistry
  • Oxidation-Reduction
  • Temperature
  • Water / chemistry

Substances

  • Alcohols
  • Aldehydes
  • Cyclic N-Oxides
  • Nitriles
  • Water
  • Ammonia
  • Copper
  • TEMPO