Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance

Wan Lu Pang; Weng Tong Ho; Herbert Schwarz

doi:10.4161/onci.23441

Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance

Oncoimmunology. 2013 Apr 1;2(4):e23441. doi: 10.4161/onci.23441.

Authors

Wan Lu Pang¹, Weng Tong Ho, Herbert Schwarz

Affiliation

¹ Department of Physiology and Immunology Programme; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.

Abstract

CD137 is ectopically expressed on Hodgkin and Reed-Sternberg (HRS) cells, causing the removal of the immunostimulatory CD137 ligand from HRS cells as well as from surrounding antigen presenting cells. This inhibits T-cell co-stimulation and supports the immune evasion of Hodgkin's lymphoma.

Keywords: CD137; Reed-Sternberg cells; classical Hodgkin’s lymphoma; immune evasion.