Stabilization of activation induced cytidine deaminase by bortezomib does not confer increased drug target mutation frequency

MeSH terms

• Boronic Acids / pharmacology*
• Bortezomib
• Burkitt Lymphoma / enzymology
• Burkitt Lymphoma / genetics
• Cell Line, Tumor
• Cytidine Deaminase / chemistry
• Cytidine Deaminase / genetics*
• Cytidine Deaminase / metabolism*
• Drug Resistance, Neoplasm / genetics
• Enzyme Activation / drug effects
• Humans
• Inhibitory Concentration 50
• Mutation / drug effects*
• Mutation Rate
• Pyrazines / pharmacology*