Granulocyte colony-stimulating factor receptor T595I (T618I) mutation confers ligand independence and enhanced signaling

Leukemia. 2013 Dec;27(12):2407-10. doi: 10.1038/leu.2013.164. Epub 2013 Jun 6.

Authors

H M Mehta¹, T Glaubach, A Long, H Lu, B Przychodzen, H Makishima, M A McDevitt, N C P Cross, J Maciejewski, S J Corey

Affiliation

¹ Department of Pediatrics (Hematology-Oncology) and Cell and Molecular Biology, Lurie Children's Hospital of Chicago, and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

PMID: 23739288
DOI: 10.1038/leu.2013.164

No abstract available

Publication types

Letter

MeSH terms

Humans
Ligands
Mutation*
Receptors, Granulocyte Colony-Stimulating Factor / genetics*
Signal Transduction*

Substances

Ligands
Receptors, Granulocyte Colony-Stimulating Factor

Grants and funding

R01 CA108922/CA/NCI NIH HHS/United States