A pediatric case of New Delhi metallo-β-lactamase-1-producing Enterobacteriaceae in the United States

Pediatr Infect Dis J. 2013 Nov;32(11):1291-4. doi: 10.1097/INF.0b013e31829eca34.

Abstract

We report the second pediatric case of New Delhi metallo-β-lactamase-1-producing Enterobacteriaceae in the United States. Laboratory methods included various phenotypic antimicrobial susceptibility testing assays, as well as polymerase chain reaction assays for carbapenemase-encoding genes. Laboratory challenges and the limited number of effective antimicrobial agents and the lack of pediatric-specific safety and efficacy data for these drugs are discussed.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Child
  • Enterobacteriaceae / classification
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / isolation & purification
  • Enterobacteriaceae Infections / drug therapy
  • Enterobacteriaceae Infections / microbiology*
  • Female
  • Fosfomycin / pharmacology
  • Fosfomycin / therapeutic use
  • Humans
  • Microbial Sensitivity Tests
  • Minocycline / analogs & derivatives
  • Minocycline / pharmacology
  • Minocycline / therapeutic use
  • Tigecycline
  • United States
  • beta-Lactam Resistance
  • beta-Lactamases / biosynthesis*

Substances

  • Anti-Bacterial Agents
  • Fosfomycin
  • Tigecycline
  • beta-Lactamases
  • beta-lactamase NDM-1
  • Minocycline