Freshwater lake of the Tibetan plateau has great ecological value and extreme vulnerability. The water samples have been collected in Daggyaima Co at an altitude of 5 080 m +/- 10 m. This study has investigated the sources, the major controlling factors of the major ions, and hydrochemical evolution trend according to the hydrochemical composition of water samples. The results showed that the major cations and anion of lake water were Ca(2+), Na(+) and HCO3(-), respectively, and the hydrochemical type was HCO3 -Ca, The total dissolved solid (TDS) was in the range of 71.2-199.8 mg x L(-1). The concentrations of EC, Ca(2+) and HCO3(-) in water samples from Southeast areas were relatively low resulted from the rich aluminum and poor calcium of geological background and the dilution effect of surface runoff. The Na(+)/(Na(+) + Ca(2+)) of water samples was 0.08-0.75, Cl(-) /(Cl(-) + HCO3(-)) was 0.11-0.35, Ca/Na was 0.58, Mg/Ca was 0.12, and HCO3/Na was 1.46, which suggested that the hydrochemical composition of the lake water was mainly controlled by silicate rock weathering based on Gibbs model and analysis of elemental stoichiometry. The minerals participated in weathering processes included plagioclase (anorthite, albite), potassium feldspar, biotite, calcite, dolomite, gypsum, rock salt, etc. The average value of K/Na was 0.059, indicating the weathering level of potassium feldspar was relatively low. The saturation index (SI) of calcite, dolomite, gypsum, quartz and hematite contained in the lake was higher than zero, while the SI of rock salt was lower than 0, revealing the trend that the freshwater lake is turning into salt water lake in Tibetan Plateau.