Abstract
The chimeric bla(CTX-M-123) gene was identified in two ceftazidime-resistant Escherichia coli isolates from animals in different Chinese provinces. Like other CTX-M-1/9 group hybrids (CTX-M-64 and CTX-M-132), the ends (amino acids 1 to 135 and 234 to 291) of CTX-M-123 match CTX-M-15 while the central part (122 to 241) matches CTX-M-14. bla(CTX-M-123) is carried on related, but not identical, ~90-kb IncI1 plasmids in the two isolates, and one isolate simultaneously carries the group 1 blaCTX-M-55 gene on an additional IncI2 plasmid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Base Sequence
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Ceftazidime / pharmacology
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China
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Escherichia coli / drug effects
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Escherichia coli Proteins / classification
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism*
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Genes, Bacterial*
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Homologous Recombination
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutant Chimeric Proteins / genetics
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Mutant Chimeric Proteins / metabolism*
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Plasmids / genetics
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Plasmids / metabolism
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beta-Lactamases / classification
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Bacterial Proteins
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Escherichia coli Proteins
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Mutant Chimeric Proteins
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Ceftazidime
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CTX-M-9 protein, E coli
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beta-lactamase TEM-3
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beta-Lactamases
Associated data
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GENBANK/JN790864
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GENBANK/KC160505
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GENBANK/KC576516
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GENBANK/KC576517