A sustainable two-phase procedure for V-catalyzed toluene oxidative bromination with H2O2-KBr

Dalton Trans. 2013 Sep 7;42(33):11963-70. doi: 10.1039/c3dt50907a.

Abstract

A sustainable V(V) and Mo(VI) catalysed two-phase procedure for bromination of toluene under quite mild conditions is proposed; H2O2 is the primary oxidant and KBr is the bromine source; metal precursors are commercially available salts. The reaction is efficient without any additional solvent. By using PhCH3 as a solvent/substrate good yields, together with interesting selectivity toward the formation of PhCH2Br, are obtained with both metal ions. Recycling of the catalytic phase is also possible. Useful information on the V-peroxido chemistry was obtained.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bromides / chemistry*
  • Catalysis
  • Hydrocarbons, Brominated / chemical synthesis*
  • Hydrocarbons, Brominated / chemistry
  • Hydrogen Peroxide / chemistry*
  • Molecular Structure
  • Molybdenum / chemistry
  • Oxidation-Reduction
  • Potassium Compounds / chemistry*
  • Toluene / chemistry*
  • Vanadium / chemistry*

Substances

  • Bromides
  • Hydrocarbons, Brominated
  • Potassium Compounds
  • Vanadium
  • Toluene
  • Molybdenum
  • Hydrogen Peroxide
  • potassium bromide