Bcgitis and vaccine-derived poliovirus infection in a patient with a novel deletion in RAG1 binding site

Int J Immunopathol Pharmacol. 2013 Apr-Jun;26(2):511-5. doi: 10.1177/039463201302600225.

Abstract

A girl who developed severe BCGitis and vaccine-derived poliovirus infection was discovered to have a novel deletion of RAG1. A neonatal screening program for SCID would identify affected infants at birth, before live vaccines are administered.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Antiviral Agents / therapeutic use
  • BCG Vaccine / administration & dosage
  • BCG Vaccine / adverse effects*
  • Base Sequence
  • Binding Sites
  • DNA Mutational Analysis
  • Disease Progression
  • Fatal Outcome
  • Female
  • Gene Deletion*
  • Genetic Predisposition to Disease
  • Homeodomain Proteins / genetics*
  • Humans
  • Immunization Schedule
  • Immunocompromised Host / genetics*
  • Infant
  • Molecular Sequence Data
  • Phenotype
  • Poliomyelitis / chemically induced*
  • Poliomyelitis / drug therapy
  • Poliomyelitis / immunology
  • Poliovirus Vaccine, Oral / administration & dosage
  • Poliovirus Vaccine, Oral / adverse effects*
  • Severe Combined Immunodeficiency / diagnosis
  • Severe Combined Immunodeficiency / genetics*
  • Severe Combined Immunodeficiency / immunology
  • Tuberculosis, Lymph Node / chemically induced*
  • Tuberculosis, Lymph Node / drug therapy
  • Tuberculosis, Lymph Node / immunology
  • Tuberculosis, Pulmonary / chemically induced*
  • Tuberculosis, Pulmonary / drug therapy
  • Tuberculosis, Pulmonary / immunology

Substances

  • Antitubercular Agents
  • Antiviral Agents
  • BCG Vaccine
  • Homeodomain Proteins
  • Poliovirus Vaccine, Oral
  • RAG-1 protein