A controlled-release nanocarrier with extracellular pH value driven tumor targeting and translocation for drug delivery

Angew Chem Int Ed Engl. 2013 Jul 15;52(29):7487-91. doi: 10.1002/anie.201302557. Epub 2013 Jun 11.

Abstract

This pHLIP is no flop: Functionalizing mesoporous silica nanoparticles (MSNs) with pHLIPss peptide provides a controlled-release nanoparticle drug delivery system targeting the acidic tumor microenvironment. At low pH values, pHLIPss inserts into the cell membrane and translocates carriers into cells, where the cargo is released by the cleavage of the pHLIPss disulfide bonds (see scheme).

Keywords: drug delivery; mesoporous silica nanoparticle; nanocarriers; pHLIP; targeted release.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Delayed-Action Preparations
  • Doxorubicin / administration & dosage
  • Doxorubicin / toxicity
  • Drug Carriers / chemistry*
  • Humans
  • Hydrogen-Ion Concentration
  • MCF-7 Cells
  • Nanoparticles / chemistry
  • Neoplasms / drug therapy
  • Peptides / chemistry
  • Porosity
  • Silicon Dioxide / chemistry

Substances

  • Delayed-Action Preparations
  • Drug Carriers
  • MCM-41
  • Peptides
  • Silicon Dioxide
  • Doxorubicin