Are C-reactive protein and ferritin levels being overlooked in indigenous australians with chronic kidney disease?

J Ren Care. 2013 Sep;39(3):176-81. doi: 10.1111/j.1755-6686.2013.12015.x. Epub 2013 Jun 14.

Abstract

Background: Indigenous Australians have significantly higher rates of end-stage renal disease and worse health outcomes than non-indigenous Australians.

Objectives: We investigated whether the effect of inflammation on C-reactive protein (CRP) and ferritin levels is being overlooked in indigenous patients with chronic kidney disease.

Design: Data for 23,000 patients were extracted from the Renal Anaemia Management database for the period November 1999 to October 2010.

Measurement: Haemoglobin, ferritin, transferrin saturation and CRP levels for indigenous and non-indigenous Australians were compared with target levels given in the Caring for Australians with Renal Impairment (CARI) guidelines.

Results: Compared with non-indigenous patients, indigenous Australians had higher median CRP and mean ferritin levels, lower mean haemoglobin level and were less likely to meet CARI targets.

Conclusion: The effect of inflammation on laboratory parameters should be considered particularly when treating indigenous Australians.

Keywords: C-reactive protein; Chronic kidney disease; Ferritin; Indigenous Australians; Inflammation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anemia, Iron-Deficiency / blood
  • Anemia, Iron-Deficiency / ethnology
  • Anemia, Iron-Deficiency / nursing
  • Australia
  • C-Reactive Protein / metabolism*
  • Female
  • Ferritins / blood*
  • Hemoglobinometry
  • Humans
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / ethnology*
  • Kidney Failure, Chronic / nursing*
  • Male
  • Middle Aged
  • Population Groups*
  • Reference Values
  • Risk Factors
  • Transferrin / metabolism

Substances

  • Transferrin
  • C-Reactive Protein
  • Ferritins